In conclusion, these results show that chronic, prolonged NO exposure promotes malignant characteristics including altered morphology, chromosomal and genomic instability, increased TP53 mutation, as well as the induction of stemness signaling mediators including CD44 and COX2 in human MCF10A breast epithelial cells, which may in part explain increased cancer risks in patients with inflammatory diseases [4,5]. This evidence concerns the gene CD44 and cancer.