Multiple neoplasms, including head and neck cancer [41], gastric cancer [42], lung cancer [43], ovarian cancer [44], astrocytic tumors [45], breast cancer [46], glioma [47], B cell lymphoma [48], pancreatic cancer [49], and skin cancer have reported mutations within TP53, PIK3CA and KRAS mutation hot spot regions [50]. The gene discussed is PIK3CA; the disease is familial pancreatic carcinoma.