[57] In addition, it has been observed that IL1β-induced NOS2 expression greatly enhances the KRAS activating mutation via the activation of promoters on NF-κβ, C/EBP, and CRE-like sites, indicating that NO generation by NOS2 is involved in the tumor-promoting actions of activated KRAS [58]. The gene discussed is CEBPA; the disease is neoplasm.