Despite some of the studies on CAV1 and CAV2 in HNSCC have collected basic information, such as gene expression and analysis of survival, to prove the potential mechanism underlying the promotional effect and possibly the inhibitory effect in HNSCC progression [6], the accurate role that CAV1 and CAV2 play in HNSCC is still indistinct. This evidence concerns the gene CAV2 and head and neck squamous cell carcinoma.