The results show that two signaling pathways, cellular protein catabolic process (ES = 0.42) and proteasome complex (ES = 0.72), which is the primary degrading mechanism for oxidatively damaged proteins as well as a number of proteins involved in the cell cycle and transcription, both of which are crucial for cancer development, obtaining strong correlation with the high expression of CAV2 in HNSCC patients, indicating their significant relation with HNSCC [14]. The gene discussed is CAV2; the disease is cancer.