HNSCC contains tumors of multiple sites, including tonsils, hypopharynx, palate, oropharynx, etc. The expression of CAV1 was lowest in tonsil cancer and highest in palate cancer, and the expression of CAV2 was lowest in tonsil cancer and highest in hypopharynx cancer. This evidence concerns the gene CAV2 and head and neck squamous cell carcinoma.