We found that the higher expression of CAV1 was negatively correlated with T cell regulatory (Tregs) (partial.cor = −0.341 p = 6.82 × 10−15) and positively correlated with CD8 + T cells (partial.cor = 0.383 p = 1.36 × 10−18), CD4 + T cells (partial.cor = 0.285 p = 1.19 × 10−10) and B cells (partial.cor = 0.164 p = 2.65 × 10−4) via searching the relationship between the expression levels of CAV1 and CAV2 and the infiltration degree of different types of cells in immune microenvironment in HNSCC. Here, CAV1 is linked to head and neck squamous cell carcinoma.