Other clinicopathological parameters, including age, gender pathological stage, T stage, N stage and M stage, were correlated with the prognosis of patients with HNSCC via Cox regression analysis, indicating that CAV1 expression may be a prognostic factor of DSS and OS, and CAV2 expression may be an independent prognostic factor of DSS, OS and PFI. Here, CAV2 is linked to head and neck squamous cell carcinoma.