The binding ratio of [125I]BIP-NMe2 (Figure 9a) in the gray matter of the temporal lobe compared with the frontal lobe was 12.9, and autoradiographic studies in AD brains show selectivity of [18F]IBIPF1 (Figure 9b) and [18F]IBIPF2 (Figure 9c) tau for aggregates compared with Aβ [204]. Here, MAPT is linked to Alzheimer disease.