Medial temporal AD brain homogenates containing a high density of tau and a moderate density of Aβ showed higher affinity of [18F]THK-5105 (Figure 3b) (KD = 2.6 nM) and [18F]THK-5117 (Figure 3d) (KD = 5 nM) than for [18F]THK-523 (Figure 2f) (KD = 87 nM). The gene discussed is MAPT; the disease is Alzheimer disease.