Similarly, a diagnostic model for CS-associated AP (GSE149607) showed high performance based on the four selected genes (ICAM1, TNFRSF1A, CD83, and CXCR5), with AUC values of 0.996 (95% CI:0.9852-1), 0.889 (95% CI:0.6711-1), and 0.993 (95% CI:0.9797-1). The gene discussed is TNFRSF1A; the disease is Cowden syndrome 1.