Li M et al. reported that the stimulation of native TRPV4 or transiently transfected TRPV4 in A375 cells (human melanoma cell line) could induce significant extracellular secretion, which acquired TRPV4-mediated calcium influx, as well as a series of key regulators of exocytosis including lysosome-associated proteins and multiple folding and vesicular transporters. This evidence concerns the gene TRPV4 and melanoma.