Lin R et al. added PKC/MEK inhibitor to BxPC-3 cells overexpressing TRPM2 and demonstrated that TRPM2 might directly activate PKCα via calcium or indirectly activate PKCε and PKCδ by increasing DAG in pancreatic cancer, which promoted pancreatic cancer by the activation of the downstream MAPK/MEK pathway [45]. This evidence concerns the gene PRKCA and familial pancreatic carcinoma.