To study ACDase’s role in the inflammatory infiltrate found in ulcerative colitis, Obeid et al. developed a myeloid-specific ACDase conditional knockout mouse model, Mye AC cKO, by crossing the floxed Asah1 mice from Eliyahu’s study with strain B6.129P2-Lyz2tm1(cre)Ifo/J [31,49]. Here, ASAH1 is linked to ulcerative colitis.