METTL14 promotes endothelial inflammation and atherosclerotic plaque formation by mediating m6A modification of forkhead box O1 (FOXO1) [140], and ischemia-induced ALKBH5 facilitates endothelial angiogenesis by mediating demethylation of sphingosine kinase 1 (SPHK1) [141]. This evidence concerns the gene SPHK1 and ischemia.