The clinical significance of the immune-suppressive response that HSPs may induce was shown in seminal studies by van Eden et al. [21,22,23], who used specific peptide sequences of mycobacterial HSP to stimulate protective self-HSP cross-reactivity to induce the IL-10-mediated suppression of adjuvant arthritis, colitis and autoimmune encephalitis. This evidence concerns the gene IL10 and autoimmune encephalitis.