RAX2 and cone-rod dystrophy 11: Retina and anterior neural folding homeobox 2 (RAX2) acts as a transcriptional coactivator in that it cooperatively interacts with CRX to trans activate photoreceptor-specific genes [329].Alternative splicing variant mutations in Rax2, the gene encoding RAX2, have been associated with cone-rod dystrophy type 11 and RP [330].