INS and diabetes mellitus: Mapping the variants from our screen to the binding sites of two different solved full receptor and insulin interactions (Figure 8B) showed potential for diabetes-associated variants at amino acids H29, L30, H34, L35, L39, V42, G44, R46, G47, F48, F49, Y50, V92, E93, T97, S98, S101, Y103, and Y108 (Figure 8C,D).