In addition, metformin inhibits angiogenesis and attenuates tumor migration by attenuating angiogenic stimulation, downregulating VEGF expression, inhibiting HIF-1α-induced angiogenesis-related factor expression and reducing the signaling of platelet-derived growth factor B (PDGF-B) and PDGF-receptorβ (PDGF-Rβ) [183,184,185,186]. The gene discussed is HIF1A; the disease is neoplasm.