These include downregulating the signal transducer and the activator of transcription 3 (STAT3)/Bcl2/Beclin1 signaling pathway activity in cancer cells, disrupting unfolded protein response (UPR) transcription, blocking the oncogenic Wnt signaling pathway, regulating caspase enzyme activity, increasing reactive oxygen species (ROS) production by cancer cells, inhibiting the activation of mTORC1 by Rag GTPases and inhibiting glutaminase activity [142,143,144,145,146,147,148,149]. Here, GLS is linked to cancer.