The effect of P53 in tumor apoptosis was also associated with the reduced expression of transcription factor specificity protein 1 (Sp1), Sp3, Sp4 and oncogenes (B-cell lymphoma-2 (BCL-2), mTOR, vascular endothelial growth factor (VEGF) and MYC, etc.)[103,104];. This evidence concerns the gene VEGFA and neoplasm.