METTL3 and colorectal cancer: Song et al. discovered that in colorectal cancer, METTL3 catalyzed m6A modification in 3’UTR of HSF1 mRNA and protein expression of HSF1 was significantly downregulated after knockdown of YTHDF1, demonstrating that METTL3-mediated m6A could promote translation through the m6A reader YTHDF1 [65].