In chronic myeloid leukemia (CML), investigators found the presence of METTL3 in the cytoplasm, then they verified that METTL3 knockdown led to a reduction in global translation efficiency in CML cells and showed a critical role for METTL3 in maintaining ribosome levels and translational potential [82]. Here, METTL3 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.