A study on T2D and control subjects undergoing a hyperinsulinemic clamp found that prothrombotic platelet proteins, namely P-selectin, platelet factor 4, platelet glycoprotein VI, and PAI-1, were elevated in T2D subjects in comparison to control subjects [42], making them more susceptible to thromboembolic events. This evidence concerns the gene PF4 and type 2 diabetes mellitus.