UMOD and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: Moreover, mutations in the uromodulin gene (UMOD) cause autosomal dominant tubulointerstitial kidney disease or medullary cystic kidney disease and some variants are associated with the development of hypertension and chronic kidney disease, which proves its important role in the correct development and functioning of the kidney [98,99,100].