EGFR and non-small cell lung carcinoma: In-frame, tandem duplication of EGFR exons 18–25, encoding EGFR kinase domain duplication (EGFR-KDD), has been identified in patients with NSCLC [105], with cases of a duplication of exons 14–26, 17–25 and 18–26 also reported in NSCLC [106].