SPOCD1 and colorectal carcinoma: To investigate the biological roles of SPOCD1 in CRC, we first identified the top 50 positively significant genes associated with SPOCD1, as shown in the heatmap (Figure 3A), in which solute carrier family 11 member 1 (SCL11A1) was the gene most correlated with SPOCD1 expression (Figure 3B).