SPOCD1 mRNA expression level was substantially elevated in malignant cancers as opposed to their matched normal counterparts, particularly in the case of stomach adenocarcinoma (STAD), breast cancer (BRCA), head and neck squamous cell carcinoma (HNSC), colon adenocarcinoma (COAD), and rectum adenocarcinoma (READ) (Figure 1A,B). This evidence concerns the gene SPOCD1 and breast cancer.