SPOCD1 and colorectal carcinoma: Table 1 provides an overview of the associations between clinicopathological factors and SPOCD1 expression in 644 CRC patients. When compared to individuals with lowered SPOCD1 levels, those with elevated SPOCD1 levels were at a more advanced pathological stage (p = 0.037), N stage (p = 0.043), and T stage (p = 0.014). In addition, IHC staining also revealed increased expression of SPOCD1 in stage III and IV CRC compared with stage I and II CRC (Figure 2I,J).