A number of proteins, including Jun-activating binding protein-1, HIF1, IκB-α, p27, p21, and p53, that are linked to cancer, neurodegenerative diseases, inflammatory response, oxidative stress, skeletal muscle development, and uterine fibroblast proliferation, are regulated by UCHL1 [23,37,38,39,40]. Here, TP53 is linked to neurodegenerative disease.