Compared to NSCLC, SCLC patients had a more suppressed state of blood DC (both of MDC and PDC) and more risk factors at the baseline, such as the presence of brain/liver metastases, high NLR, a high amount of HLA-DRlow MDSC, low amounts of slan+ non-classical monocytes, and low amounts of CD1c+ MDC. The gene discussed is CD1C; the disease is small cell lung carcinoma.