NOX4 and Hyperglycemia: Though, in some cases, a significant effect of hyperglycaemia in μg was observed, such as the stimulation of a higher count and larger-sized MCS formation, the upregulation of the expression of the pro-oxidative enzyme NOX4 and the apoptotic proteins NF-κB and CASP3, and a more pronounced downregulation of fibronectin and transglutaminase-2.