AKT1 and cancer: For example, luteolin has been shown to induce cancer cell apoptosis by inhibiting the dual inhibition of the MAPK and PI3K signaling pathways in gastric cancer cells [37], promote neuronal survival and reduce neuronal apoptosis through the phosphatidylinositol 3-kinase/Akt signaling pathway [38], and attenuate methamphetamine-induced apoptosis by inhibiting the PI3K/Akt pathway [39].