NFKB1 and pancreatitis: The triggering of pancreatitis occurs through intra-acinar cell activation of zymogens, leading to self-digestion of the gland, with cationic trypsinogen being the isoform responsible for cell death at the beginning of pancreatitis, which occurs due to the activation of NF-kB that may be involved in the progression of the local and systemic lesion [37].