ADIPOQ exogenous administration to type 2 diabetes-induced mice showed an increase of testicular steroidogenic activities, insulin receptor and glucose transporter 8 proteins, and glucose and lactate intra-testicular concentrations [37], thus supporting the idea that ADIPOQ improves testicular functions also through the increase of intra-cellular energy substrate transport and the reduction of oxidative stress [37]. This evidence concerns the gene INSR and type 2 diabetes mellitus.