CXCL8 and juvenile polyposis syndrome: In arthroplasty studies targeting specific transcripts, those associated with neutrophil activation, such as calprotectin, and IL-8, and macrophage inflammatory transcripts, such as chemokine (C-X-C motif) ligand (CXCL) 2 (CXCL2), and chemokine (C-C motif) ligand (CCL) 3 (CCL3), are elevated in PJI and associated with bone degeneration through bone-resorbing osteoclast generation, as well as induction of osteoblast inflammatory cytokine production [190,208,209].