The most common reasons for exclusion included hematologic malignancy (including acute myeloid leukemia (AML) and acute lymphocytic leukemia (ALL)) and QTc prolongation (>500 ms) or elevated aspartate transferase (AST)/alanine aminotransferase (ALT) five times the upper limit of normal precluding the use of fluconazole. The gene discussed is GPT; the disease is acute lymphoblastic leukemia.