Santa-Mara et al. [23] reported the presence of CoQ10 in paired helical filaments (aberrant protein aggregates containing tau protein) and in Hirano bodies (neuronal inclusions that are mainly observed in hippocampal neurons and are composed of actin either associated with or not associated with tau) in brain patients with AD, and state that CoQ10 was able to induce the formation of aggregates when it was mixed with tau and actin. The gene discussed is MAPT; the disease is Alzheimer disease.