In vitro, dietary flavonoids induce apoptosis by increasing apoptotic protein expression, ROS production, intracellular caspase-9, caspase-3, Apaf-1, and caspase-3 level, and decreasing AKT expression, inhibiting autography, and STAT3 signaling; Flavonoids modulate autography through inhibiting mTOR signaling pathway and proteasome; Flavonoids target NF-κB to inhibit cancer development and inflammatory responses. Here, AKT1 is linked to cancer.