A previous study has shown that the levels and activities of antioxidant enzymes such as peroxiredoxin 1, 2 and 6 (Prx 1, 2 and 6), glutathione peroxidases 1 and 6 (GPX1 and 6) and mitochondrial superoxide dismutase in the HD striatum and cortex were markedly elevated [172], presumably as a countermeasure to the prevalent oxidative stress. Here, GPX1 is linked to Huntington disease.