Fetuin-A is involved in a number of pathophysiological regulations, such as insulin receptor signaling, adipocyte dysfunction and inflammation, liver fibrosis, lipid toxicity, triacylglycerol production, macrophage phenotype modification, promotion of angiogenesis, β-cell damage/apoptosis and TLR4 activation, which are critical for liver integrity and function [146,147,148]. This evidence concerns the gene AHSG and Hepatic fibrosis.