Mancini et al. [100] measured plasma CoQ10 levels in a series of patients with disorders of the pituitary–adrenal axis, including 6 patients with ACTH-dependent adrenal hyperplasia; 19 patients with secondary isolated hypoadrenalism, and 19 patients with associated hypothyroidism (multiple pituitary deficiencies). The gene discussed is POMC; the disease is congenital adrenal hyperplasia.