Related to Nrf2, it seems that continuous and prolonged activation of this factor increases the risk of malignancies and creates an environment favorable to the development, proliferation, and creation of resistance to chemotherapy and radiotherapy through antioxidant mechanisms [188,189] At the same time, it is suggested that CBD reduces the transcription of Nrf2, manifesting in this way the protection of cells [190]. This evidence concerns the gene NFE2L2 and cancer.