NOS2 and Alzheimer disease: On the same note, NF-κB, a factor sensitive to changes in oxidative homeostasis, which is activated by the family of stress-activated protein kinases (SAPKs), which includes p38 MAPK, regulates the transcription of pro-inflammatory factors and the immune response, but also induces iNOS in neurons affected by the presence of Aβ, both in cell cultures and in post-mortem studies on the brains of AD patients [149,150,151].