The NRF2 activation of the STCs was elucidated by determining the NQO1 induction (Prochaska microtiter plate assay) and expression of representative antioxidant genes (HMOX1, NQO1, GCLC, GCLM, TXNRD1, PRDX1, GPX2, GSTP1, GSTM2, GSTA1, and G6PDX by qPCR) in mouse hepatoma (Hepa-1c1c7) cells. Here, HMOX1 is linked to hepatocellular carcinoma.