Similarly, in another randomized, double-blind, crossover trial, a 30-day supplementation schedule of C3 Complex (500 mg/day) along with piperine (5 mg/day) significantly reduced levels of inflammatory cytokines IL-1β and IL-4 in subjects with obesity, indicating the potential anti-inflammatory role of curcumin in obesity treatment [104]. This evidence concerns the gene IL4 and obesity due to melanocortin 4 receptor deficiency.