TXN and infection: Nuclear factor erythroid-derived 2-related factor 2 (Nrf2) provides the main cytoprotective defense system in the host cell and is known as a master regulator of tissue damage and disease tolerance to infection via the coordinated regulation of the glutathione (GSH) and thioredoxin (Txn) antioxidant system, heme and iron metabolism, ROS, and xenobiotic detoxification to avoid DNA damage and cell death [10].