Additionally, to induce NASH, CHIP+/+ and CHIP+/− mice were fed chow (11.5% fat, 0% sucrose) or HF–HS (36% fat, 30% sucrose) diet for 22 weeks, and body and fat weight, IPGTT, and IPITT were measured. The gene discussed is STUB1; the disease is metabolic dysfunction-associated steatohepatitis.