STUB1 and Hepatic steatosis: To determine whether CHIP plays a role in TM-induced hepatic steatosis in vivo, CHIP+/+ and CHIP+/− mice were challenged with TM (2 μg/g body weight, i.p.)for 8 h or 36 h, and histological analyses were performed on liver tissue sections from TM-injected CHIP+/+ mice and CHIP+/− mice.