Lee et al. reported that hepatic IRE1α/XBP1 controls the expression of lipogenic enzymes (SCD1, ACC2, and DGAT2), which are crucial for fatty acid and cholesterol biosynthesis [49], whereas the IRE1α and/or ATF6 play a role in preventing ER stress-dependent hepatic steatosis [50,51]. This evidence concerns the gene SCD and fatty liver disease.