Furthermore, it showed that the transcriptional alteration of mRNA levels of genes involved in lipogenesis (ACC), fatty acid oxidation (PPARα) and lipid uptake (CD36, FATP1) by the HF–HS diet was significantly reversed in liver tissues from CHIP+/− mice, but not APOB, a marker of the VLDL secretion pathway (Figure 4h). This evidence concerns the gene PPARA and hydrops fetalis.