CYBB and Parkinson disease: NOX2 activation and H2O2 production are induced by PD toxins, including 6-hydroxydopamine (6-OHDA), 1-Methyl-4-phenylpyridin-1-ium (MPP+), and rotenone, favoring AMPK and Akt/mTOR signaling pathways and apoptosis in neuronal cells [80].