Yan et al. found that in a mouse model of PD induced by MPTP, a nigrostriatal dopaminergic neurotoxin, the protein expression of NOX2 increased coincidentally with increased α-Syn Ser129 and reduced autophagy flux, suggesting a role for NOX2-mediated oxidative stress and autophagy in PD pathogenesis [81]. The gene discussed is CYBB; the disease is Parkinson disease.