Oxidative stress has been implicated in the pathogenesis of cardiovascular diseases [86] and NOX2 has emerged as the primary source of ROS in vascular diseases, such as hypercholesterolemia [87,88,89,90,91,92,93] atherosclerosis, and thrombotic complications [35] as well as in cardiac diseases, including myocardial infarction (MI) [94,95,96,97,98,99]. This evidence concerns the gene CYBB and Hypercholesterolemia.