Thereby, polyphenols can modulate specific mechanisms of action in well-investigated cancer pathways, the most targeted intracellular processes being p53-regulated mechanisms (that is a central element for cell cycle and apoptosis), MAPK pathway (central signaling cascades involved in the control of cell growth, differentiation, survival, and cell death), PI3K/Akt/mTOR pathway (which control essential cellular functions such as proliferation, transcription, translation, survival, growth survival, growth, metastasis, and drug chemoresistance) [40]. The gene discussed is TP53; the disease is cancer.