HMGA2 and melanoma: In a research study, Zhang et al. found that a non-cytotoxic concentration of diphenyl difluoroketone (EF24), a curcumin analog, could suppress cell mobility and EMT on Lu1205 and A375 melanoma cell lines by increasing the expression of miR-33b, a direct suppressor of high-mobility group AT-hook 2 (HMGA2) [150].