HMGA2 and melanoma: In a research article from 2016, Yamada et al. observed that EGCG, a natural polyphenol found in green tea, upregulates miRNA let-7b expression by activating 67 kDa laminin receptor signaling led to downregulation of tumor suppression target gene HMGA2 in mouse melanoma B16, human melanoma Mewo and A375 cells.