In contrast, responses to the endothelium-dependent vasodilator, bradykinin, were attenuated in vessels that had been incubated with highly concentrated glucose solution (HG, 25 mM D-glucose) compared to vessels incubated in physiologically concentrated glucose solution (NG, 5.5 mM D-glucose) (Figure 1C), which is indicative of endothelial dysfunction. The gene discussed is KNG1; the disease is endothelial dysfunction.