NQO1 and cancer: In this review, I summarize current advancements in the study of NQO1 functionality depending upon post-translational modifications on its protein sequence, as well as by mutations and polymorphisms found in cancer cell lines and human populations with uncertain associations with disease (in contrast to the very common, largely inactivating and cancer-associated polymorphism P187S) [1,13,14,15]), which may highly determine NQO1 activity in different individuals.