Besides, the activation of the pathway can significantly up-regulate the expression of prostate tumor stem cell markers B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1), Aldehyde dehydrogenase 1A1 (ALDH1A1), Cluster of differentiation-44 (CD44), aldehyde dehydrogenase 1 family, member A3 (ALDH1A3), and SOX2 mRNA [9]. Here, ALDH1A3 is linked to prostate neoplasm.