Several studies have demonstrated that estrogen deficiency and inflammatory diseases, including diabetes, chronic kidney disease, rheumatoid arthritis, and periodontitis, upregulate FGF23 and osteoclastogenic factors through osteocyte apoptosis and the production of inflammatory cytokines, with subsequent alteration of the osteogenic and mineralization process [28,31,40,72]. Here, FGF23 is linked to chronic kidney disease.