This review showed that OS, together with proinflammatory factors and various interleukins, such as IL-1, IL-6, IL-11, and TNFα, constitutes one of the main factors leading to the impairment of bone metabolism and contributes to the pathogenesis of various forms of osteoporosis related to estrogen deficiency, aging, prolonged pharmacological treatments, and effects secondary to inflammatory processes. The gene discussed is IL11; the disease is osteoporosis.