The innate immune receptor TLR4 has not been fully explored as a therapeutic target in the clinical rheumatology field [38], nonetheless, its signaling crosstalks with IL1R [39,40,41] a well-explored therapeutic target for OA [42,43,44,45,46,47,48,49] and RA [50,51]. The gene discussed is IL1R1; the disease is rheumatoid arthritis.