NOX4 and Ureteral obstruction: A recent study found that NKT supplementation at the dose of 10 mg/kg per day for 14 or 28 consecutive days could effectively inhibit the inflammatory response, apoptosis, and fibrosis in the kidney tissues in a unilateral ureteral obstructive mouse model by partly inhibiting the NAD(P)H oxidase-4 (NOX4)/ROS pathway and TGF-β1 pathway [21].