Thus, tumors derived from Prx4−/− and Prx4−/−/Srx−/− mice are likely to be more sensitive to oxidative stress, which may combine with the lower cell proliferation rates to partially explain the decreased tumor multiplicity and volume found in Prx4−/− and Prx4−/−/Srx−/− mice. This evidence concerns the gene PRDX4 and neoplasm.