In the current study, we used both female and male mice and demonstrated that although male mice developed more urethane-induced tumors than females, Prx4−/− and Prx4−/−/Srx−/− mice have significantly lower tumor multiplicity and volume in both genders, which suggests that Prx4-Srx depletion confers resistance to urethane-induced lung cancer. Here, PRDX4 is linked to lung cancer.