After counting the number of tumors (≥0.2 mm) and measuring their diameters, we found that the average number of tumors per mouse (tumor multiplicity) in either the Prx4−/− or Prx4−/−/Srx−/− group is significantly reduced (by around 40%) compared with that of the wild-type group (Figure 1D). This evidence concerns the gene SRXN1 and neoplasm.