Sows are prone to being overweight in late pregnancy, which causes structural, metabolic, and functional changes in various tissues and organs, aggravating progressive oxidative stress [56], insulin resistance [57], and systemic inflammation [53] with high levels of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukins (IL-1, IL-6, and IL-8), and C-reactive protein (CRP) [58,59], leading to placental lipid toxicity [60]. Here, TNF is linked to Insulin resistance.