In addition, TLR4 is known to induce VEGF expression in prostate tumors related to interaction with hypoxia inducible factor-1 α (HIF-1α); VEGF enhances the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in the tumor microenvironment [49]. The gene discussed is NFKB1; the disease is prostate neoplasm.