OTUD1 and autoimmune disease: Although WT OTUD1 drastically suppressed poly(I:C)-induced NF-κB and IFN-sensitive response element (ISRE) activation, the autoimmune disease-associated P95R, R243C, P379S, and P420L mutants, as well as a DUB-inactive C320S mutant, attenuated the inhibitory effects of OTUD1 on the innate immune response.