Grattoarola et al. reported that chemoresistant pancreatic ductal adenocarcinoma (PDAC) cell lines, such as PANC-1 cells, expressed higher levels of nuclear factor erythroid 2-related factor 2 (Nrf2), HO-1, YAP, and survive longer than those in chemosensitive PDAC cell lines with reduced oxidative stress [32]. This evidence concerns the gene NFE2L2 and pancreatic ductal adenocarcinoma.