There are about 100 human DUBs, which are classified into seven subfamilies: 56 members of ubiquitin-specific proteases (USPs), 17 ovarian tumor proteases (OTUs), 4 ubiquitin C-terminal hydrolases (UCHs), 4 Machado–Josephin domain-containing proteases (MJDs), 5 motif interacting with ubiquitin-containing novel DUBs (MINDYs) [6], 1 zinc finger with the UFM1-specific peptidase domain protein (ZUFSP) [7], and 12 JAB1/MPN/Mov34 metalloenzymes (JAMM/MPN+) [8,9]. The gene discussed is PRSS27; the disease is neoplasm.