Through their database analysis, Liu et al. note that among the OTU family DUBs, the mRNA levels of OTUD1, OTUD2, OTUD6B, and OUTD7B are downregulated in ccRCC, while those of OTUD3, OTUD6A, and A20 are upregulated, and the downregulation of OTUD1 is the key for the poor prognosis of ccRCC patients. Here, OTUD3 is linked to nonpapillary renal cell carcinoma.