Interestingly, these findings in GBM fit with a report showing that MFRN1 and MFRN2 are required for the increased proliferation of osteosarcoma cells exposed to excess iron but contrast with the report that reduced expression of MFRN1 in hepatocellular carcinoma cells promotes cell survival and tumor growth [60], further demonstrating the importance of thoroughly investigating the function of the mitoferrins by cancer cell type and conditions. This evidence concerns the gene SLC25A28 and osteosarcoma.