In this context, a study realized on rats exposed to a maternal high-fat diet during pregnancy, resveratrol supplementation (10 mg/kg) managed to restore the impaired expression of SIRT1, phosphor-extracellular regulated kinases1/2, (p-ERK1/2) and phospho-peroxisome proliferator-activated receptor γ (PPARγ), adiponectin and Brain-Derived Neurotrophic Factor (BDNF), all molecules involved in insulin resistance and mild cognitive dysfunction [77]. Here, BDNF is linked to Insulin resistance.