Variants of the gap junction protein beta-2 (Gjb2) and gap junction protein beta-6 (Gjb6) genes, encoding connexin 26 (Cx26) and connexin 30 (Cx30), respectively, have been linked to the deafness DFNB1, the most frequent non-syndromic hearing loss in the Mediterranean population [78]. This evidence concerns the gene GJB6 and deafness.