Their bioactive compounds ameliorate oxidative stress-induced kidney damage, enhance the antioxidant system, and decrease the inflammatory process and fibrosis, most likely by activating the KEAP1/Nrf2/ARE pathway and by deactivating the NFB pathway [102].The activation of Nrf2 results in the upregulation of several antioxidant enzymes and cytoprotective genes, such as SOD, CAT, glutathione peroxidase (GPx), and heme oxygenase-1(HO-1). This evidence concerns the gene KEAP1 and Nephropathy.